Clinical Literature
Six papers worth your afternoon.
The most-cited peer-reviewed research and regulatory validation behind Pure2Cure — curated for clinicians, food-safety leaders, and operators.
Hypochlorous Acid: A Review
A clinical review of HOCl as an inexpensive, non-toxic, and effective sanitizer against SARS-CoV-2 — covering production, stability, application methods, and oral-maxillofacial use.
- HOCl inactivates a variety of viruses including coronaviruses in <1 min
- 200 ppm decontaminates surfaces in 1 min; 20 ppm in 10 min
- Endogenous to neutrophils — safe for skin, mucosa, and food contact
- On-site generation eliminates supply-chain and shelf-life issues
Hypochlorous Acid (HOCl) as a Promising Respiratory Antiseptic
A peer-reviewed exploration of HOCl-based nasal sprays, mouthwashes, and inhalation for bacterial and viral respiratory infections — RSV, influenza, and SARS-CoV-2.
- Aerosolized HOCl up to ~26 ppm shown safe for respiratory tissue in vitro
- Cleaves solvent-exposed disulfide bridges (C480–C488) in SARS-CoV-2 RBD
- Influenza A strains more susceptible than SARS-CoV-2 to low-dose HOCl
Applications of Electrolyzed Water in Agriculture & Food Industries
A comprehensive review of HOCl/electrolyzed water across the farm-to-table chain — seed disinfection, irrigation, post-harvest washing, food contact surface sanitation, and aerial fungicide spraying.
- HOCl is FDA-permitted for processing meat, poultry, fish, fruits, and vegetables
- 50 ppm AEW achieves ≥7-log E. coli O157:H7 kill in 1 min at 45 °C
- Effective against thin-walled fungi (Botrytis, Monilinia) in <30 seconds
Issues Surrounding the Stability of Hypochlorous Acid as a Disinfectant
Examines why bottled HOCl degrades — pH, temperature, UV exposure, organic load, and metal ions — and why on-site generation is the only way to guarantee fresh, potent disinfectant at the point of use.
- pH 5.0–6.5 is the optimal stability + potency window
- Above 25 °C, HOCl degrades into less-effective hypochlorite
- UV/sunlight causes photolysis; storage must be dark and cool
- On-site generation is the most reliable mitigation strategy
A Potential Benefit of Hypochlorous Acid — Facial Sanitisation
Argues for HOCl as a facial sanitizer — covering its anti-inflammatory action, dermatological benefits, biofilm disruption, and safety on eyelids, lips, and even infant skin.
- Endogenously produced by neutrophils — body has antioxidant defense to safely scavenge
- Mayo Clinic SkinSafe: hypoallergenic, eyelid/lip-safe, safe for babies
- Anti-inflammatory: reduces IL-6 cytokine binding to its receptor
WHO Expert Committee Review on Hypochlorous Acid
Global regulatory validation: the WHO Expert Committee recommends adding HOCl to the Essential Medicines List for antisepsis, citing its superiority over povidone-iodine in safety, efficacy, and biofilm activity.
- FDA-approved for food contact, high-level disinfection, and wound care
- EMA-approved as Class III medical device for wound management
- Strong evidence for diabetic foot wounds; moderate for septic surgery
